480 Tests
Microplate Neonatal 17-OHP Assay
CAH is an inborn error of metabolism that results from an inherited recessive defect in any of the five enzymatic steps required to synthesize cortisol from cholesterol. Complete or partial deficiency of 21-hydroxylase leads to elevated levels of 17a-OH progesterone (17-OHP) in 90% to 95% of all CAH cases.
CAH exists in several forms: Classical [Salt Wasting (SW), Simple Virilizing (SV)], and Non-Classical (NC). If left untreated, the SW form can result in life-threatening adrenal crises within the first weeks of life and precocious growth in both sexes. Non-classical CAH may result in persistent slight elevations of 17-OHP from birth with clinical mani-festations occurring later in life.
The Bio-Rad Microplate Neonatal 17-OHP Assay is a quantitative assay for the determination of 17a-hydroxyprogesterone in neonatal dried blood spot specimens.
The Bio-Rad Assay is:
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Free of background interferences common with fluorometric assay methods
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Conveniently packaged with all reagents provided in each kit
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Performed with any microplate reader
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Easily automated
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